【报告人】：Dr.Bruce A. Bunnell
【报告地点】：G01-E402会议室
【报告时间】：2015年4月13日下午1：30
报告摘要：
Subcutaneous adipose tissue has emerged as a viable alternative tissue source for stromal/stem cells for use in regenerative medicine. Research efforts focused on adipose derived stem cells across the globe have established a wealth of basic science and preclinical evidence regarding the differentiation potential and regenerative properties of both freshly processed, heterogeneous stromal vascular fraction cells and culture expanded, more homogeneous adipose-derived stromal/stem cells (ASCs). It is becoming evident that in many disease models that the levels of improvement mediated by ASCs does not always correlate with the levels of cellular engraftment, persistence and differentiation. As such, differentiation may not be a primary mechanism by which ASCs mediate tissue repair. Similar to mesenchymal stem cells isolated from the bone marrow (BMSCs), it has been reported that ASCs secrete bioactive levels of soluble factors (macromolecules, growth factors and cytokines) capable of regulation of diverse disease-associated processes, including activation of tissue-resident stem/progenitor cells, apoptosis, stimulation of vasculogenesis and inhibition of inflammation. A rapidly growing body of literature indicates that ASCs possess potent immunosuppressive properties. The stage has been set for clinicians to translate adipose-derived cells from the bench to the bedside and in fact human clinical trials for several disease states are underway or have been completed. The goal for this presentation is to discuss the biologic properties, mechanisms of repair and clinical testing of SVF and ASCs.
报告人简介：
Bio for Dr.Bruce A. Bunnell
Director, Tulane Center for Stem Cell Research and Regenerative Medicine
Professor of Pharmacology
Department of Pharmacology
Tulane University School of Medicine
New Orleans, LA
Dr. Bunnell is a Professor of pharmacology and the Director of Tulane Center for Stem Cell Research and Regenerative Medicine. He began his career at Tulane in 2002. His research interests are focused on characterization of mesenchymal stem cells and their use in treatment of various diseases. Dr. Bunnell received his B. S. in Developmental Biology from Purdue University. Following his bachelor’s program, Bunnell went to graduate school and completed his doctoral studies at the University of Alabama at Birmingham. He has co-authored approximately 120 peer reviewed papers and 7 book chapters.
