专题：Opportunities and challenges in cancer prevention and kava as a case study

授课时间：2016年7月12日13:30-15:00（2学时）

授课地点：A 01主教学楼W101房间

主讲人：Prof Chengguo Xing

听课班级：石油与化学工程学院2014、2015级本科生，欢迎研究生和老师参加。

【主讲人简介】

Prof Chengguo Xing

Department Medicinal Chemistry University of Minnesota/Florida

1991-1996 BS: Dalian University of Technology

1996-2001 Ph.D.: Arizona State University

2001-2003 Postdoc: Harvard University

2003-2016 Professor: U of Minnesota

【授课内容简介】

Cancer is one of the leading causes of death in humans – due to many factors, the total incidence and mortality is steadily increasing globally, which results in tremendous health, social and financial burdens. Surgery, therapy, early diagnosis, and their combinations have been the main clinical practice to help manage this deadly disease with significant achievements. However, given that it generally takes years or even decades for most malignancies to present the clinical symptom since initiation, preventative approach is necessary to be integrated in our future practice in order to achieve more optimal outcome.

With the increasing understanding of tumorigenesis process, cancer prevention is becoming more and more feasible, which is envisioned as a great opportunity for future scientists. The goal of this lecture therefore is to help build some fundamental basis of cancer prevention research. The first part of this lecturewill provide anoverview of tumorigenesis process, the factors leading to cancer development, and the need and success of cancer prevention, including cancer statistics, cancer aetiology, carcinogenesis, and current status in cancer prevention. The second part of the lecture will discuss a case study performed in the Xing’s research group – the development of kava as a promising cancer chemopreventive agent. We will cover its epidemiological indication, its efficacy in preclinical animal models1-3, its quality control and quality assurance1, the identification of the active ingredients4, the mechanism of action5, the potential of hepatotoxicity6, some preliminary results of an ongoing human trial, and its future opportunities.