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张秀娟

姓名: 张秀娟

院系: 石油与化工学院

办公电话:0427-2631967

电子信箱: xiujuanzhang@dlut.edu.cn

其他专业:

个人简介

主要学历:

96.9-01.7,

大连理工大学,化工学院,化工外贸(英语强化)学士;

01.9---03.12,

大连理工大学,化工学院,硕士研究生;

04.1---09.12,

美国杜兰(Tulane)大学,化学与生物分子工程系,工学博士。

工作简历:

2010/01-2013/06,美国杜兰(Tulane)大学,医学院干细胞研究与再生医学中心,博士后。

2013/07-现在,大连理工大学石油与化工学院,副教授。

研究领域(研究课题)

研究领域:

生物化工;功能纳米材料;干细胞研究;干细胞组织工程;基因治疗。

研究课题:

纳米材料在基因传递及医药传递中的应用;

干细胞对炎症疾病的治疗;

干细胞对肿瘤的影响及治疗。

近五年主要研究成果:

1. Zhang X, Bowles A, Semon JA, Scruggs BA, Zhang S, Strong AL, Gimble JM, Bunnell BA*. Transplantation of Autologous Adipose Stem Cells Lacks Therapeutic Efficacy in the Experimental Autoimmune Encephalomyelitis Model. PLoS ONE, 9:e85007. 2014.

2. Zhang X, Semon JA, Zhang S, Strong AL, Scruggs BA, Gimble JM, Bunnell BA*. Characterization of Adipose-derived Stromal/Stem Cells from the Twitcher Mouse Model of Krabbe Disease. BMC Cell Biology, 14:20, 2013.

3. Zhang X#, Dobek G#, Balazs DA, Godbey WT*. Analysis of Promoters and Expression-targeted Gene Therapy, Optimization Based on Cell Behavior. FASEB J., 25:3219-3228, 2011. (# the first two authors contributed equally to the paper).

4. Zhang X,Godbey WT*. Preclinical Evaluation of a Gene therapy Treatment for Transitional Cell Carcinoma. Cancer Gene Ther., 18:34-41, 2011.

5. Scruggs BA,Zhang X, Bowles AC, Gold PA, Semon JA., Fisher-Perkins JM., Zhang S, Bonvillain RW, Myers L, Li SC, Kalueff AV, Bunnell BA*. Multipotent stromal cells alleviate inflammation, neuropathology, and symptoms associated with globoid cell leukodystrophy in the twitcher mouse. Stem Cells, 31:1523-1534, 2013.

6. Semon JA,Zhang X, Pandey AC, Alandete SM, Maness C, Zhang S, Scruggs BA, Strong AL, Sharkey SA, Beuttler MM, Gimble JM, Bunnell BA*. Administration of murine stromal vascular fraction ameliorates chronic experimental autoimmune encephalomyelitis. Stem Cells Transl Med., 2:789-796, 2013.

7. Semon JA, Maness C,Zhang X, Sharkey SA, Beuttler MM, Shah FS, Pandey AC, Gimble JM, Zhang S, Scruggs BA, Strong AL, Strong TA, Bunnell BA*. Comparison of human adult stem cells from adipose tissue and bone marrow in the treatment of experimental autoimmune encephalomyelitis. Stem Cell Res Ther., 5:2, 2014.

8. Scruggs BA, Semon JA,Zhang X, Zhang S, Bowles AC, Pandey AC, Imhof KM, Kalueff AV, Gimble JM, Bunnell BA*. Age of the donor reduces the ability of human adipose-derived stem cells to alleviate symptoms in the experimental autoimmune encephalomyelitis mouse model. Stem Cells Transl Med., 2:797-807, 2013.

9. Scruggs BA, Bowles AC,Zhang X, Semon JA, Kyzar EJ, Kalueff AV, Bunnell BA*. Automated Neurophenotyping of Twitcher Mice allows for High-Throughput Therapeutic Screening for Globoid Cell Leukodystrophy. Behav Brain Res., 236:35-47, 2012.

10. Strong AL, Strong TA, Rhodes LV, Semon JA,Zhang X, Gimble JM, Burow ME, Bunnell BA*. Obesity associated alterations in the biology of adipose stem cells mediate enhanced tumorigenesis by estrogen dependent pathways. Breast Cancer Res., 15:R102, 2013.

11. Wicks S, Londot H, Zhang B, Dowden J, Klopf-Eiermann J, Fisher-Perkins J, Trygg C, Scruggs B,Zhang X, Gimble J*, Bunnell B, Pistell P. Effect of Intrastriatal Mesenchymal Stromal Cell Injection on Progression of a Murine Model of Krabbe Disease. Behav Brain Res., 225:415-425, 2011.

专著:

1. Zhang X, Balazs DA, and Godbey WT, Nanobiomaterials for Non-viral Gene Therapy, CRC Press/Taylor & Francis Group, 2011. Chapter 13: 1-28.

Scruggs BA,Zhang X, Gimble JM and Bunnell BA. Stem Cell-based Therapy for Lysosomal Storage Diseases, Springer: Stem Cells and Human Diseases, 2012. Chapter 3:61-90.

 
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